Target deconvolution of bioactive small molecules: the heart of chemical biology and drug discovery
정혜진, 권호정,
소속 상세정보
정혜진 ( Jung Hye-Jin )
Sun Moon University Department of BT-Convergent Pharmaceutical Engineering
권호정 ( Kwon Ho-Jeong )
Yonsei University College of Life Science and Biotechnology Department of Biotechnology
KMID : 0043320150380091627
Abstract
Identification of the target proteins of bioactive small molecules isolated from phenotypic screens plays an important role in chemical biology and drug discovery. However, discovering the targets of small molecules is often the most challenging and time-consuming step for chemical biology researchers. To overcome the bottlenecks in target identification, many new approaches based on genomics, proteomics, and bioinformatics technologies have been developed. Here, we provide an overview of the current major methodologies for target deconvolution of bioactive small molecules. To obtain an integrated view of the mechanisms of action of small molecules, we propose a systematic approach that involves the combination of multi-omics-based target identification and validation and preclinical target validation.
키워드
Small molecule; Target identification; Chemical biology; Drug discovery
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