EGFR and KRAS Mutations in Patients With Adenocarcinoma of the Lung
장태원, 서순정, 옥철호, 정만홍, 장희경,
소속 상세정보
장태원 ( Jang Tae-Won )
고신대학교 의과대학 내과학교실
서순정 ( Seo Soon-Jung )
이수앱지스
옥철호 ( Oak Chul-Ho )
고신대학교 의과대학 내과학교실
정만홍 ( Jung Maan-Hong )
고신대학교 의과대학 내과학교실
장희경 ( Chang Hee-Kyung )
고신대학교 의과대학 해부병리학교실
KMID : 0338420090240010048
Abstract
Background/Aims:Mutations of the epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene (KRAS) are important in the pathogenesis of lung cancer, and recent reports have revealed racial and geographical differences in mutation expression.
Methods:This study was conducted to investigate the prevalence of EGFR and KRAS mutations and their correlation with clinical variables in Korean patients with adenocarcinoma of the lung. Formalin-fixed adenocarcinoma specimens from 104 randomly selected patients diagnosed at Kosin University Gospel Hospital from October 1996 to January 2005 were used for the study.
Results:We found a high prevalence of EGFR mutations and a low prevalence of KRAS mutations. EGFR mutations were present in 24% (25 of 104) of the samples: one mutation in exon 18, 13 in exon 19, one in exon 20, and 10 in exon 21. The presence of an EGFR mutation was not associated with gender, smoking history, histological grade, age, bronchioalveolar components, or cancer stage in patients with adenocarcinoma of the lung.
Conclusion:Mutations of KRAS were present in 9.6% (9 of 94) of the samples: eight in codon 12 and one in codon 13. EGFR mutations were never found in tumors with KRAS mutations, suggesting a mutually exclusive relationship.
키워드
Adenocarcinoma; EGFR; KRAS; Lung cancer; Mutation
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