Triiodothyronine Levels Are Independently Associated with Metabolic Syndrome in Euthyroid Middle-Aged Subjects
김혜정, 배지철, 박형규, 변동원, 서교일, 유명희, 김재현, 민용기, 김선욱, 정재훈,
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김혜정 ( Kim Hye-Jeong )
Soonchunhyang University College of Medicine Soonchunhyang University Hospital Department of Internal Medicine
배지철 ( Bae Ji-Cheol )
Sungkyunkwan University School of Medicine Samsung Changwon Hospital Department of Medicine Division of Endocrinology and Metabolism
박형규 ( Park Hyeong-Kyu )
Soonchunhyang University College of Medicine Soonchunhyang University Hospital Department of Internal Medicine
변동원 ( Byun Dong-Won )
Soonchunhyang University College of Medicine Soonchunhyang University Hospital Department of Internal Medicine
서교일 ( Suh Kyo-Il )
Soonchunhyang University College of Medicine Soonchunhyang University Hospital Department of Internal Medicine
유명희 ( Yoo Myung-Hi )
Soonchunhyang University College of Medicine Soonchunhyang University Hospital Department of Internal Medicine
김재현 ( Kim Jae-Hyeon )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Medicine
민용기 ( Min Yong-Ki )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Medicine
김선욱 ( Kim Sun-Wook )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Medicine
정재훈 ( Chung Jae-Hoon )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Medicine
KMID : 0356620160310020311
Abstract
Background: Recent studies have shown an association between thyroid hormone levels and metabolic syndrome (MetS) among euthyroid individuals; however, there have been some inconsistencies between studies. Here, we evaluated the relationship between thyroid hormone levels and MetS in euthyroid middle-aged subjects in a large cohort.
Methods: A retrospective analysis of 13,496 euthyroid middle-aged subjects who participated in comprehensive health examinations was performed. Subjects were grouped according to thyroid stimulating hormone, total triiodothyronine (T3), total thyroxine (T4), and T3-to-T4 ratio quartile categories. We estimated the odds ratios (ORs) for MetS according to thyroid hormone quartiles using logistic regression models, adjusted for potential confounders.
Results: Of the study patients, 12% (n=1,664) had MetS. A higher T3 level and T3-to-T4 ratio were associated with unfavourable metabolic profiles, such as higher body mass index, systolic and diastolic blood pressure, triglycerides, fasting glucose and glycated hemoglobin, and lower high density lipoprotein cholesterol levels. The proportion of participants with MetS increased across the T3 quartile categories (P for trend <0.001) and the T3-to-T4 ratio quartile categories (P for trend <0.001). The multi-variate-adjusted OR (95% confidence interval) for MetS in the highest T3 quartile group was 1.249 (1.020 to 1.529) compared to the lowest T3 quartile group, and that in the highest T3-to-T4 ratio quartile group was 1.458 (1.141 to 1.863) compared to the lowest T3-to-T4 ratio quartile group, even after adjustment for potential confounders.
Conclusion: Serum T3 levels and T3-to-T4 ratio are independently associated with MetS in euthyroid middle-aged subjects. Longitudinal studies are needed to define this association and its potential health implications.
키워드
Thyroid hormones; Triiodothyronine; Metabolic syndrome
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