난소를 절제한 마우스에서 갱년기증후군에 대한 오미자의 효과
Effects of Schisandrae Fructus on menopause symptoms in ovariectomized mice
신다솜, 홍성빈, 금정호, 마진열, 정환석,
소속 상세정보
신다솜 ( Shin Da-Som )
경희대학교 한의과대학 생리학교실
홍성빈 ( Hong Seong-Bin )
바이오믹스 생명과학연구소
금정호 ( Geum Jeong-Ho )
바이오믹스 생명과학연구소
마진열 ( Ma Jin-Yeul )
한국한의학연구원 한의기술응용센터
정환석 ( Chung Hwan-Suck )
한국한의학연구원 한의기술응용센터
KMID : 0363620160370030039
Abstract
Objectives: The present study aimed at investigating the effects of Schisandrae Fructus (SF) on menopause symptoms in ovariectomized mice.
Methods: 6 weeks old female mice were ovariectomized (OVX), and the OVX mice were fed with a three doses of SF (25, 100, and 400 mg/kg, respectively) or 17β-estradiol (E2, 0.5 mg/kg) 3 times a week for 6 weeks. Body weight was measured at every week and uterus weight was also measured at the end of experiment. Lipids and osteocalcin levels in serum were analyzed.
Results: The uterine weight was not changed in SF treated group, while E2 intake increased the reduced uterine weight by OVX. Although Body weight was increased since two weeks after ovariectomy compared with sham operated group, there was no change in SF or E2 treated group compared with OVX. But LDL was significantly reduced in SF (400 mg/kg) or E2 fed mice and SF or E2 treatment decreased enhanced osteocalcin level by OVX.
Conclusion: These results indicated that SF would be effective in the improvement of LDL level and osteoporosis on menopause.
키워드
Menopause; Schisandrae fructus; Ovariectomized mice; Osteoporosis; Osteocalcin
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