Evaluation of the role of TAX, HBZ, and HTLV-1 proviral load on the survival of ATLL patients
Akbarin Mohammad Mehdi, Shirdel Abbas, Bari Alireza, Mohaddes Seyedeh Tahereh, Rafatpanah Houshang, Karimani Ehsan Ghayour, Etminani Kobra, Golabpour Amin, Torshizi Reza,
소속 상세정보
( Akbarin Mohammad Mehdi )
Mashhad University of Medical Sciences Faculty of Medicine Inflammation and Inflammatory Diseases Research Center
( Shirdel Abbas )
Mashhad University of Medical Sciences Faculty of Medicine Ghaem Hospital Department of Hematology
( Bari Alireza )
Mashhad University of Medical Sciences Faculty of Medicine Ghaem Hospital Department of Hematology
( Mohaddes Seyedeh Tahereh )
Mashhad University of Medical Sciences Faculty of Medicine Ghaem Hospital Department of Hematology
( Rafatpanah Houshang )
Mashhad University of Medical Sciences Faculty of Medicine Inflammation and Inflammatory Diseases Research Center
( Karimani Ehsan Ghayour )
Razavi Hospital Department of Research and Education Molecular Diagnostic Unit
( Etminani Kobra )
Mashhad University of Medical Sciences Faculty of Medicine Department of Medical Informatics
( Golabpour Amin )
Mashhad University of Medical Sciences Faculty of Medicine Department of Medical Informatics
( Torshizi Reza )
Mashhad University of Medical Sciences Faculty of Medicine Department of Modern Sciences and Technologies
KMID : 0366220170520020106
Abstract
Background: Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy with very poor prognosis and short survival, caused by the human T-lymphotropic virus type-1 (HTLV-1). The HTLV-1 biomarkers trans-activator x (TAX) and HTLV-1 basic leucine zipper factor (HBZ) are main oncogenes and life-threatening elements. This study aimed to assess the role of the TAX and HBZ genes and HTLV-1 proviral load (PVL) in the survival of patients with ATLL.
Methods: Forty-three HTLV-1-infected individuals, including 18 asymptomatic carriers (AC) and 25 ATLL patients (ATLL), were evaluated between 2011 and 2015. The mRNA expression of TAX and HBZ and the HTLV-1 PVL were measured by quantitative PCR.
Results: Significant differences in the mean expression levels of TAX and HBZ were observed between the two study groups (ATLL and AC, P =0.014 and P=0.000, respectively). In addition, the ATLL group showed a significantly higher PVL than AC (P=0.000). There was a significant negative relationship between PVL and survival among all study groups (P =0.047).
Conclusion: The HTLV-1 PVL and expression of TAX and HBZ were higher in the ATLL group than in the AC group. Moreover, a higher PVL was associated with shorter survival time among all ATLL subjects. Therefore, measurement of PVL, TAX, and HBZ may be beneficial for monitoring and predicting HTLV-1-infection outcomes, and PVL may be useful for prognosis assessment of ATLL patients. This research demonstrates the possible correlation between these virological markers and survival in ATLL patients.
키워드
HTLV-1; ATLL; TAX; HBZ; Proviral load
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