RBL-2H3 세포에서 Cyanidin-3-glucoside의 Th2 사이토카인 발현 억제 효과
Suppressive Effects of Cyanidin-3-glucoside on Th2 Cytokines Production in RBL-2H3 Cells
약학회지 2013년 57권 5호 p.309 ~ 315
정화현, 윤수정, 표명운,
소속 상세정보
정화현 ( Jeong Hwa-Hyun )
숙명여자대학교 약학대학
윤수정 ( Yoon Soo-Jeong )
숙명여자대학교 약학대학
표명운 ( Pyo Myoung-Yun )
숙명여자대학교 약학대학
KMID : 0370220130570050309
Abstract
Cyanidin-3-glucoside (C3G), an anthocyanin, is one of the most widespread dietary flavonoids. We investigated the effects of C3G in PMA/ionomycin (PI)-induced RBL-2H3 cells. C3G inhibited the production of IL-4 and IL-13 and also decreased the level of mRNA in a dose-dependent manner. Furthermore, western blot analysis implied that C3G down-regulated the protein level of c-Jun, NF-ATc1 and NF-${\kappa}B$ 수식 이미지 but not c-Fos. Taken together, we suggest that C3G may have suppressive effects on Th2 cytokines and will be studied further to develop as functional foods that help alleviate allergy symptoms.
키워드
cyanidin-3-glucoside; IL-4; IL-13; RBL-2H3 cells; antiallergy
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