Cytotoxic Activity of the Extracts from Curcuma zedoaria
Kim Myoun-Gae, 김정선, 홍종기, JI Ming-Jie, 이용규,
소속 상세정보
( Kim Myoun-Gae )
Dongseo University
김정선 ( Kim Jung-Sun )
동서대학교
홍종기 ( Hong Jong-Ki )
Korea Baic Science Institute
( JI Ming-Jie )
Sandong University China
이용규 ( Lee Yong-Kyu )
동서대학교
KMID : 0379520030190040293
Abstract
The effect of the hexane extract of Curcuma zedoaria roots and its solvent fractions were investigated on the proliferation of SiHa, SNU-1 and HepG2 cell lines. Among those fractions, final fraction H2-3-1 and H2-3-3 showed cytotoxic effect on SiHa and HepG2 cell lines. The hallmark of apoptosis, DNA fragmentation, also appeared in the final fractions H2-3-1 and H2-3-3 after 24h treatment in SiHa cell line. Furthermore, those fractions were shown to be able to induce cell death in [^3H]thymidine incorporation test. These two fractions, H2-3-1 and H2-3-3 were determined as (-)-alpha-curcumene and beta-tumerone respectively by NMR and mass spectrum. From these results, it is speculated that te hexane extract of Curcuma zedoaria is necessary for further studies as a potent inhibitor of the growth of cancer cells.
키워드
Curcuma zedoaria roots;Hexane fraction;SiHa cells;Cytotoxicity;DNA fragmentation;Apoptosis inducer.
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