t(3;5)(q25;q34)를 동반한 소아 급성골수성백혈병 1예
A Pediatric Case of Acute Myeloid Leukemia with t(3;5)(q25;q34)
김보영, 전인상,
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김보영 ( Kim Bo-Young )
가천대학교 의학전문대학원 소아과학교실
전인상 ( Jeon In-Sang )
가천대학교 의학전문대학원 소아과학교실
KMID : 0387820140210020149
Abstract
Acute myeloid leukemia (AML) with t(3;5)(q25;q34), belonging to AML with myelodys-plasia related changes according to WHO classification in 2008, is a subtype of AML that is particularly rare in children. NPM1/MLF1 fusion gene produced as a result of t(3;5)(q25;q34) was cloned, however, the exact mechanism of its role in leukemogenesis has not been clarified. Although this cytogenetic abnormality is regarded as an inter-mediate risk factor, its clinical significance is controversial until now. More cases need to be reported and investigated, therefore we present a case of AML with t(3;5)(q25;q34) in a 14-year-old girl with literature review.
키워드
Acute myeloid leukemia; t(3;5)(q25;q34); NPM; MLF
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