Synthetic Bacteria for Therapeutics
Vo Phuong N. Lam, 이향미, 나도균,
소속 상세정보
( Vo Phuong N. Lam )
Chung-Ang University School of Integrative Engineering
이향미 ( Lee Hyang-Mi )
Chung-Ang University School of Integrative Engineering
나도균 ( Na Do-Kyun )
Chung-Ang University School of Integrative Engineering
Abstract
Synthetic biology builds programmed biological systems for a wide range of purposes such as improving human health, remedying the environment, and boosting the production of valuable chemical substances. In recent years, the rapid development of synthetic biology has enabled synthetic bacterium-based diagnoses and therapeutics superior to traditional methodologies by engaging bacterial sensing of and response to environmental signals inherent in these complex biological systems. Biosynthetic systems have opened a new avenue of disease diagnosis and treatment. In this review, we introduce designed synthetic bacterial systems acting as living therapeutics in the diagnosis and treatment of several diseases. We also discuss the safety and robustness of genetically modified synthetic bacteria inside the human body.
키워드
Synthetic biology; synthetic bacterium-based therapies; living therapeutics; disease diagnosis; metabolic diseases; cancer
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