Humoral Immunity against SARS-CoV-2 and the Impact on COVID-19 Pathogenesis
이은진, 오지은,
소속 상세정보
이은진 ( Lee Eun-Jin )
Korea Advanced Institute of Science and Technology Graduate School of Medical Science and Engineering
오지은 ( Oh Ji-Eun )
Korea Advanced Institute of Science and Technology Graduate School of Medical Science and Engineering
Abstract
It has been more than a year since severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first emerged. Many studies have provided insights into the various aspects of the immune response in coronavirus disease 2019 (COVID-19). Especially for antibody treatment and vaccine development, humoral immunity to SARS-CoV-2 has been studied extensively, though there is still much that is unknown and controversial. Here, we introduce key discoveries on the humoral immune responses in COVID-19, including the immune dynamics of antibody responses and correlations with disease severity, neutralizing antibodies and their cross-reactivity, how long the antibody and memory B-cell responses last, aberrant autoreactive antibodies generated in COVID-19 patients, and the efficacy of currently available therapeutic antibodies and vaccines against circulating SARS-CoV-2 variants, and highlight gaps in the current knowledge.
키워드
COVID-19; humoral immunity; neutralizing antibody; SARS-CoV-2; SARS-CoV-2 variants
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