중독 정신 병리의 이해 : 뇌영상 연구를 중심으로
Neurobiology of Addiction Based on Neuroimaging Evidence
민정아, 김대진,
소속 상세정보
민정아 ( Min Jung-Ah )
가톨릭대학교 의과대학 서울성모병원 정신과학교실
김대진 ( Kim Dai-Jin )
가톨릭대학교 의과대학 서울성모병원 정신과학교실
KMID : 0605620110180020061
Abstract
Substance addiction is a chronically relapsing disorder that has been characterized by a vicious cycle composed of intoxication, craving/anticipation, withdrawal, and response inhibition/bingeing. Here we summarize the findings from neuroimaging studies in addiction according to these behavioral components and suggest the integrated neurobiological model of drug addiction and related brain correlates. The roles of various prefrontal regions, thalamus, memory circuit, anterior cingulated, and insula were also suggested in addition to those of classical mesolimbic dopaminergic system and its responsivity. Limited studies of behavioral addiction demonstrated a similarity with substance addiction on the neurobiological basis. Based on the current understanding of neurobiology of addiction, further researches on interactions of behavioral components and their brain correlates, behavioral addiction, and therapeutic applications will be desired.
키워드
Substance addiction; Neurobiology; Neuroimaging
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