Mechanisms regulating intestinal barrier integrity and its pathological implications
Chelakkot Chaithanya, 김재왕, 류성호,
소속 상세정보
( Chelakkot Chaithanya )
Pohang University of Science and Technology Division of Integrative Biosciences and Biotechnology
김재왕 ( Ghim Jae-Wang )
NovaCell Technology Inc.
류성호 ( Ryu Sung-Ho )
Pohang University of Science and Technology Department of Life Sciences
Abstract
The gastrointestinal tract is a specialized organ in which dynamic interactions between host cells and the complex environment occur in addition to food digestion. Together with the chemical barrier of the mucosal layer and the cellular immune system, the epithelial cell layer performs a pivotal role as the first physical barrier against external factors and maintains a symbiotic relationship with commensal bacteria. The tight junction proteins, including occludin, claudins, and zonula occludens, are crucial for the maintenance of epithelial barrier integrity. To allow the transport of essential molecules and restrict harmful substances, the intracellular signaling transduction system and a number of extracellular stimuli such as cytokines, small GTPases, and post-translational modifications dynamically modulate the tight junction protein complexes. An imbalance in these regulations leads to compromised barrier integrity and is linked with pathological conditions. Despite the obscurity of the causal relationship, the loss of barrier integrity is considered to contribute to inflammatory bowel disease, obesity, and metabolic disorders. The elucidation of the role of diseases in barrier integrity and the underlying regulatory mechanisms have improved our understanding of the intestinal barrier to allow the development of novel and potent therapeutic approaches.
키워드
Gastrointestinal diseases; Mechanisms of disease
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등재저널 정보
SCI(E)
MEDLINE
KCI
KoreaMed
KAMS