Plant cell culture strategies for the production of natural products
Ochoa-Villarreal Marisol, Howat Susan, 홍선미, 장미옥, 진영우, Lee Eun-Kyong, Loake Gary J.,
소속 상세정보
( Ochoa-Villarreal Marisol )
University of Edinburgh School of Biological Sciences Institute of Molecular Plant Sciences
( Howat Susan )
University of Edinburgh School of Biological Sciences Institute of Molecular Plant Sciences
홍선미 ( Hong Sun-Mi )
Unhwa Corp.
장미옥 ( Jang Mi-Ok )
Unhwa Corp.
진영우 ( Jin Young-Woo )
Unhwa Corp.
( Lee Eun-Kyong )
Unhwa Corp.
( Loake Gary J. )
University of Edinburgh School of Biological Sciences Institute of Molecular Plant Sciences
KMID : 0624620160490030149
Abstract
Plants have evolved a vast chemical cornucopia to support their sessile lifestyles. Man has exploited this natural resource since Neolithic times and currently plant-derived chemicals are exploited for a myriad of applications. However, plant sources of most high-value natural products (NPs) are not domesticated and therefore their production cannot be undertaken on an agricultural scale. Further, these plant species are often slow growing, their populations limiting, the concentration of the target molecule highly variable and routinely present at extremely low concentrations. Plant cell and organ culture constitutes a sustainable, controllable and environmentally friendly tool for the industrial production of plant NPs. Further, advances in cell line selection, biotransformation, product secretion, cell permeabilisation, extraction and scale-up, among others, are driving increases in plant NP yields. However, there remain significant obstacles to the commercial synthesis of high-value chemicals from these sources. The relatively recent isolation, culturing and characterisation of cambial meristematic cells (CMCs), provides an emerging platform to circumvent many of these potential difficulties.
키워드
Cambial meristematic cells; Hairy root culture; Natural products; Plant bioreactors; Plant cell culture
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