The gut microbiota: a key regulator of metabolic diseases
양진용, 권미나,
소속 상세정보
양진용 ( Yang Jin-Young )
University of Ulsan College of Medicine Asan Medical Center Department of Convergence Medicine Mucosal Immunology Laboratory
권미나 ( Kweon Mi-Na )
University of Ulsan College of Medicine Asan Medical Center Department of Convergence Medicine Mucosal Immunology Laboratory
KMID : 0624620160490100536
Abstract
The prevalence of obesity and type 2 diabetes, two closely linked metabolic disorders, is increasing worldwide. Over the past decade, the connection between these disorders and the microbiota of the gut has become a major focus of biomedical research, with recent studies demonstrating the fundamental role of intestinal microbiota in the regulation and pathogenesis of metabolic disorders. Because of the complexity of the microbiota community, however, the underlying molecular mechanisms by which the gut microbiota is associated with metabolic disorders remain poorly understood. In this review, we summarize recent studies that investigate the role of the microbiota in both human subjects and animal models of disease and discuss relevant therapeutic targets for future research.
키워드
Gut microbiota; Metabolic disorder; Obesity; Short-chain fatty acids; Type 2 diabetes
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