DNA methylation-based age prediction from various tissues and body fluids
정상은, 신경진, 이환영,
소속 상세정보
정상은 ( Jung Sang-Eun )
Yonsei University College of Medicine Department of Forensic Medicine and Brain Korea 21 Project for Medical Science
신경진 ( Shin Kyoung-Jin )
Yonsei University College of Medicine Department of Forensic Medicine and Brain Korea 21 Project for Medical Science
이환영 ( Lee Hwan-Young )
Yonsei University College of Medicine Department of Forensic Medicine and Brain Korea 21 Project for Medical Science
Abstract
Aging is a natural and gradual process in human life. It is influenced by heredity, environment, lifestyle, and disease. DNA methylation varies with age, and the ability to predict the age of donor using DNA from evidence materials at a crime scene is of considerable value in forensic investigations. Recently, many studies have reported age prediction models based on DNA methylation from various tissues and body fluids. Those models seem to be very promising because of their high prediction accuracies. In this review, the changes of age-associated DNA methylation and the age prediction models for various tissues and body fluids were examined, and then the applicability of the DNA methylation-based age prediction method to the forensic investigations was discussed. This will improve the understandings about DNA methylation markers and their potential to be used as biomarkers in the forensic field, as well as the clinical field.
키워드
Age prediction; DNA methylation; Forensic genetics
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