Angiogenesis and vasculogenic mimicry as therapeutic targets in ovarian cancer
임단샘, 도여진, 권병수, 장우철, 이명석, 김종민, 조진구,
소속 상세정보
임단샘 ( Lim Dan-Saem )
Sookmyung Women’s University Division of Biological Science
도여진 ( Do Yeo-Jin )
Sookmyung Women’s University Division of Biological Science
권병수 ( Kwon Byung-Su )
Pusan National University School of Medicine Pusan National University Hospital Department of Obstetrics and Gynecology
장우철 ( Chang Woo-Chul )
Pusan National University College of Education Department of Biology Education
이명석 ( Lee Myeong-Sok )
Sookmyung Women’s University Division of Biological Science
김종민 ( Kim Jong-Min )
Sookmyung Women’s University Division of Biological Science
조진구 ( Cho Jin-Gu )
Sookmyung Women’s University Division of Biological Science
Abstract
Tumor angiogenesis is an essential process for growth and metastasis of cancer cells as it supplies tumors with oxygen and nutrients. During tumor angiogenesis, many pro-angiogenic factors are secreted by tumor cells to induce their own vascularization via activation of pre-existing host endothelium. However, accumulating evidence suggests that vasculogenic mimicry (VM) is a key alternative mechanism for tumor vascularization when tumors are faced with insufficient supply of oxygen and nutrients. VM is a tumor vascularization mechanism in which tumors create a blood supply system, in contrast to tumor angiogenesis mechanisms that depend on pre-existing host endothelium. VM is closely associated with tumor progression and poor prognosis in many cancers. Therefore, inhibition of VM may be a promising therapeutic strategy and may overcome the limitations of anti-angiogenesis therapy for cancer patients. In this review, we provide an overview of the current anti-angiogenic therapies for ovarian cancer and the current state of knowledge regarding the links between microRNAs and the VM process, with a focus on the mechanism that regulates associated signaling pathways in ovarian cancer. Moreover, we discuss the potential for VM as a therapeutic strategy against ovarian cancer.
키워드
Angiogenesis; Ovarian cancer; Therapeutic target; Tumor vascularization; Vasculogenic mimicry
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