Role of IL-23 and Th17 Cells in Airway Inflammation in Asthma
Hiroshi Nakajima, Koichi Hirose,
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( Hiroshi Nakajima )
Chiba University Graduate School of Medicine Departments of Molecular Genetics
( Koichi Hirose )
Chiba University Hospital Allergy and Clinical Immunology
KMID : 0923620100100010001
Abstract
Asthma is characterized by chronic airway inflammation with intense eosinophil and lymphocyte infiltration, mucus hyperproduction, and airway hyperresponsiveness. Accumulating evidence indicates that antigen-specific Th2 cells and their cytokines such as IL-4, IL-5, and IL-13 orchestrate these pathognomonic features of asthma. In addition, we and others have recently shown that IL-17-producing CD4+ T cells (Th17 cells) and IL-23, an IL-12-related cytokine that is essential for survival and functional maturation of Th17 cells, are involved in antigen-induced airway inflammation. In this review, our current understanding of the roles of IL-23 and Th17 cells in the pathogenesis of allergic airway inflammation will be summarized.
키워드
Asthma;Eosinophils;Neutrophils;IL-17;IL-23;Th17 cells
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