Regulatory T Cells in Hepatitis B and C Virus Infections
정민경, 신의철,
소속 상세정보
정민경 ( Jung Min-Kyung )
KAIST Graduate School of Medical Science and Engineering Laboratory of Immunology and Infectious Diseases
신의철 ( Shin Eui-Cheol )
KAIST Graduate School of Medical Science and Engineering Laboratory of Immunology and Infectious Diseases
KMID : 0923620160160060330
Abstract
Hepatitis B virus (HBV) and hepatitis C virus (HCV) are hepatotropic viruses that establish chronic persistent infection by effectively escaping the host immune response and can cause immune-mediated liver injury. It has recently become apparent that regulatory T (Treg) cells, specifically CD4+CD25+Foxp3+ Treg cells, modulate viral diseases by suppressing antiviral immune responses and regulating inflammatory host injury. The roles of Treg cells in HBV and HCV infections range from suppressing antiviral T cell responses to protecting the liver from immune-mediated damage. This review describes Treg cells and subpopulations and focuses on the roles of these cells in HBV and HCV infections.
키워드
Regulatory T cell; Hepatitis B virus; Hepatitis C virus
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