Damage-Associated Molecular Patterns in Inflammatory Diseases
노종성, 손동현,
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노종성 ( Roh Jong-Seong )
Pusan National University School of Medicine Department of Microbiology and Immunology
손동현 ( Sohn Dong-Hyun )
Pusan National University School of Medicine Department of Microbiology and Immunology
Abstract
Damage-associated molecular patterns (DAMPs) are endogenous danger molecules that are released from damaged or dying cells and activate the innate immune system by interacting with pattern recognition receptors (PRRs). Although DAMPs contribute to the host's defense, they promote pathological inflammatory responses. Recent studies have suggested that various DAMPs, such as high-mobility group box 1 (HMGB1), S100 proteins, and heat shock proteins (HSPs), are increased and considered to have a pathogenic role in inflammatory diseases. Here, we review current research on the role of DAMPs in inflammatory diseases, including rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, atherosclerosis, Alzheimer's disease, Parkinson's disease, and cancer. We also discuss the possibility of DAMPs as biomarkers and therapeutic targets for these diseases.
키워드
Damage-associated molecular patterns; Inflammation; Pattern recognition receptors; Inflammatory diseases
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