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The Study of the Combination of Salvia Miltiorrhiza and Kitosan on Osteoporosis in Ovariectomized Rats
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±èµµ¼º ( Kim Do-Sung )
ÀüºÏ´ëÇб³ ÀÇ°ú´ëÇÐ ¾à¸®Çб³½Ç
ÇѼÛÈñ ( Han Song-Hee )
ÀüºÏ´ëÇб³ ÀÇ°ú´ëÇÐ ¾à¸®Çб³½Ç
ÀÌ¿ëö ( Lee Yong-Chul )
ÀüºÏ´ëÇб³º´¿ø ³»°ú
¹Ú¼ºÁÖ ( Park Seong-Ju )
ÀüºÏ´ëÇб³º´¿ø ³»°ú
·ù¿ÏÈñ ( Yoo Wan-Hee )
ÀüºÏ´ëÇб³º´¿ø ³»°ú
±èÇü·æ ( Kim Hyung-Ryong )
¿ø±¤´ëÇб³ Ä¡°ú´ëÇÐ Ä¡°ú¾à¸®Çб³½Ç
äÇÑÁ¤ ( Chae Han-Jung )
ÀüºÏ´ëÇб³ ÀÇ°ú´ëÇÐ ¾à¸®Çб³½Ç
KMID : 0941820090190020075
Abstract
The preventive effect of Salvia miltiorrhiza extracts (SM) with or without high molecular weight soluble kitosan (K) on the progress of bone loss induced by ovariectomized (OVX) was studied in rats. From light microscopic analyses in histochemistry data, trabecular bone area in OVX rats was significantly decreased compared with that in sham rats. The decrease was regulated by administration of SM and especially the combination of SM and K (SM + K) for 7 weeks. In addition, the numbers of osteoblasts and osteoclasts were regulated in SM + K-administered rats but not different from those in either SM or K-administered rats. In OVX rats, free Triiodothyronine (T3) and Thyroxine (T4) were similar to control, ruling out the involvement of abnormal thyroid hormone. Although serum calcium is similar among all the groups, estrogen level was higher especially in SM+K-administered rats. These results strongly suggest that SM+K are effective in preventing the development of bone loss induced by OVX in rats.
Å°¿öµå
bone loss;ovariectomized;salvia miltiorrhiza;kitosan;T3;T4;estrogen
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