난소제거 흰쥐에서 단삼과 키토산 혼합물의 골다공증 개선효과
The Study of the Combination of Salvia Miltiorrhiza and Kitosan on Osteoporosis in Ovariectomized Rats
김도성, 한송희, 이용철, 박성주, 류완희, 김형룡, 채한정,
소속 상세정보
김도성 ( Kim Do-Sung )
전북대학교 의과대학 약리학교실
한송희 ( Han Song-Hee )
전북대학교 의과대학 약리학교실
이용철 ( Lee Yong-Chul )
전북대학교병원 내과
박성주 ( Park Seong-Ju )
전북대학교병원 내과
류완희 ( Yoo Wan-Hee )
전북대학교병원 내과
김형룡 ( Kim Hyung-Ryong )
원광대학교 치과대학 치과약리학교실
채한정 ( Chae Han-Jung )
전북대학교 의과대학 약리학교실
KMID : 0941820090190020075
Abstract
The preventive effect of Salvia miltiorrhiza extracts (SM) with or without high molecular weight soluble kitosan (K) on the progress of bone loss induced by ovariectomized (OVX) was studied in rats. From light microscopic analyses in histochemistry data, trabecular bone area in OVX rats was significantly decreased compared with that in sham rats. The decrease was regulated by administration of SM and especially the combination of SM and K (SM + K) for 7 weeks. In addition, the numbers of osteoblasts and osteoclasts were regulated in SM + K-administered rats but not different from those in either SM or K-administered rats. In OVX rats, free Triiodothyronine (T3) and Thyroxine (T4) were similar to control, ruling out the involvement of abnormal thyroid hormone. Although serum calcium is similar among all the groups, estrogen level was higher especially in SM+K-administered rats. These results strongly suggest that SM+K are effective in preventing the development of bone loss induced by OVX in rats.
키워드
bone loss;ovariectomized;salvia miltiorrhiza;kitosan;T3;T4;estrogen
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