Fecal microbiota transplantation for refractory Crohn's disease
Bak Seon-Ho, 최현호, 이진희, 김미희, 이윤희, 김진수, 조영석,
소속 상세정보
( Bak Seon-Ho )
Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Internal Medicine
최현호 ( Choi Hyun-Ho )
Catholic University College of Medicine Uijeongbu St. Mary’s Hospital Department of Internal Medicine
이진희 ( Lee Jin-Hee )
Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Internal Medicine
김미희 ( Kim Mi-Hee )
Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Internal Medicine
이윤희 ( Lee Youn-Hee )
Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Internal Medicine
김진수 ( Kim Jin-Su )
Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Internal Medicine
조영석 ( Cho Young-Seok )
Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Internal Medicine
Abstract
Approximately one-third of patients with Crohn's disease do not respond to conventional treatments, and some experience significant adverse effects, such as serious infections and lymphoma, and many patients require surgery due to complications. Increasing evidence suggests that specific changes in the composition of gut microbiota, termed as dysbiosis, are a common feature in patients with inflammatory bowel disease (IBD). Dysbiosis can lead to activation of the mucosal immune system, resulting in chronic inflammation and the development of mucosal lesions. Recently, fecal microbiota transplantation, aimed at modifying the composition of gut microbiota to overcome dysbiosis, has become a potential alternative therapeutic option for IBD. Herein, we present a patient with Crohn's colitis in whom biologic therapy failed previously, but clinical remission and endoscopic improvement was achieved after a single fecal microbiota transplantation infusion.
키워드
Crohn disease; Fecal microbiota transplantation; Dysbiosis; Biologic therapy
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