Yes-Associated Protein Expression Is Correlated to the Differentiation of Prostate Adenocarcinoma
노명균, 김성순, 황의창, 권동득, 최찬,
소속 상세정보
노명균 ( Noh Myung-Giun )
Chonnam National University Medical School Department of Pathology
김성순 ( Kim Sung-Sun )
Chonnam National University Medical School Department of Pathology
황의창 ( Hwang Eu-Chang )
Chonnam National University Medical School Department of Urology
권동득 ( Kwon Dong-Deuk )
Chonnam National University Medical School Department of Urology
최찬 ( Choi Chan )
Chonnam National University Medical School Department of Pathology
KMID : 1039420170510040365
Abstract
Background: Yes-associated protein (YAP) in the Hippo signaling pathway is a growth control pathway that regulates cell proliferation and stem cell functions. Abnormal regulation of YAP was reported in human cancers including liver, lung, breast, skin, colon, and ovarian cancer. However, the function of YAP is not known in prostate adenocarcinoma. The purpose of this study was to investigate the role of YAP in tumorigenesis, differentiation, and prognosis of prostate adenocarcinoma.
Methods: The nuclear and cytoplasmic expression of YAP was examined in 188 cases of prostate adenocarcinoma using immunohistochemistry. YAP expression levels were evaluated in the nucleus and cytoplasm of the prostate adenocarcinoma and the adjacent normal prostate tissue. The presence of immunopositive tumor cells was evaluated and interpreted in comparison with the patients’ clinicopathologic data.
Results: YAP expression levels were not significantly different between normal epithelial cells and prostate adenocarcinoma. However, YAP expression level was significantly higher in carcinomas with a high Gleason grades (8?10) than in carcinomas with a low Gleason grades (6?7) (p < .01). There was no statistical correlation between YAP expression and stage, age, prostate-specific antigen level, and tumor volume. Biochemical recurrence (BCR)?free survival was significantly lower in patients with high YAP expressing cancers (p = .02). However high YAP expression was not an independent prognostic factor for BCR in the Cox proportional hazards model.
Conclusions: The results suggested that YAP is not associated with prostate adenocarcinoma development, but it may be associated with the differentiation of the adenocarcinoma. YAP was not associated with BCR.
키워드
Yes-associated protein (YAP); Prostate adenocarcinoma; Immunohistochemistry; Gleason score
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