비만과 치매 발생의 위험: 전향적 코호트 연구의 메타 분석
Obesity and the Risk of Dementia: A Meta-Analysis of Prospective Cohort Studies
박수정, 고혜진, 윤창호, 김아솔, 문하나, 은효정,
소속 상세정보
박수정 ( Park Su-Jung )
경북대학교 의학전문대학원 가정의학교실
고혜진 ( Ko Hae-Jin )
경북대학교 의학전문대학원 가정의학교실
윤창호 ( Youn Chang-Ho )
경북대학교 의학전문대학원 가정의학교실
김아솔 ( Kim A-Sol )
칠곡경북대학교병원 가정의학과
문하나 ( Moon Han-Na )
칠곡경북대학교병원 가정의학과
은효정 ( Eun Hyo-Jeong )
경북대학교 의학전문대학원 가정의학교실
Abstract
Background: Obesity and dementia are important public health issues. Several studies have reported that obesity may increase the risk of dementia, but this has not reached a consistent conclusion. To evaluate the effect of obesity on the risk of dementia, we performed a meta-analysis of prospective cohort studies.
Methods: We systematically searched relevant studies on PubMed, Scopus, Cochrane Library, and CINAHL, which were published until November 2016. We selected prospective cohort studies about mid-life or late-life obesity and dementia based on predetermined inclusion criteria. The adjusted hazard ratio (HR) and 95% confidence interval (CI) were extracted from each study and analyzed using a random-effects model.
Results: A total of 12 studies were included in the final analysis. Compared to normal weight, mid-life or late-life obesity significantly increased the risk of dementia (HR 1.525, 95% CI 1.022?2.276; I2=93.108%, P＜0.001). In subgroup analysis, mid-life obesity increased the risk of dementia (HR 1.924, 95% CI 2.714?3.728), but late-life obesity did not show a significant result (HR 0.788, 95% CI 0.447?1.389). There were no significant differences in other subgroup analyses according to type of dementia and quality of studies. No apparent publication bias was found.
Conclusion: This study concludes that late-life and especially mid-life obesity is associated with the increased risk of dementia. It is important to control mid-life obesity to prevent late-life dementia.
키워드
Overweight; Obesity; Dementia; Alzheimer Disease; Vascular Dementia
원문 및 링크아웃 정보
등재저널 정보