Biological Role of Anti-aging Protein Klotho
±èÁöÈñ, Hwang Kyu-Hee, ¹Ú±Ô»ó, °øÀδö, Â÷¼º±Ô,
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±èÁöÈñ ( Kim Ji-Hee )
Yonsei University Wonju College of Medicine Departments of Physiology and Global Medical Science
( Hwang Kyu-Hee )
Yonsei University Wonju College of Medicine Departments of Physiology and Global Medical Science
¹Ú±Ô»ó ( Park Kyu-Sang )
Yonsei University Wonju College of Medicine Departments of Physiology and Global Medical Science
°øÀδö ( Kong In-Deok )
Yonsei University Wonju College of Medicine Departments of Physiology and Global Medical Science
Â÷¼º±Ô ( Cha Seung-Kuy )
Yonsei University Wonju College of Medicine Departments of Physiology and Global Medical Science
KMID : 1044720150050010001
Abstract
Klotho-deficient mice have accelerated aging phenotypes, whereas overexpression of Klotho in mice extends lifespan. Klotho is an anti-aging single-pass membrane protein predominantly produced in the kidney, with shedding of the amino-terminal extracellular domain into the systemic circulation. Circulating levels of soluble Klotho decrease with age, and the klotho gene is associated with increased risk of age-related diseases. The three forms of Klotho protein have distinct functions. Membrane Klotho forms a complex with fibroblast growth factor (FGF) receptors, functions as an obligatory co-receptor for FGF23, which is involved in aging and the development of chronic diseases via regulation of Pi and vitamin D metabolism. Secreted Klotho functions as a humoral factor with pleiotropic activities including regulation of oxidative stress, growth factor signaling, and ion homeostasis. Secreted Klotho is also involved in organ protection. The intracellular form of Klotho suppresses inflammation-mediated cellular senescence and mineral metabolism. Herein we provide a brief overview of the structure and function and recent research about Klotho.
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Klotho; Aging; Age-related diseases
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