Evaluation of CMV Antigenemia Assay for Diagnosis of Human Cytomegalovirus Infection
이장호, 배재춘, 손운흥, 이남용,
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이장호 ( Lee Jang-Ho )
Samsung Medical Center Department of Laboratory Medicine
배재춘 ( Bae Jae-Chun )
Samsung Medical Center Department of Laboratory Medicine
손운흥 ( Song Woon-Heung )
Samsung Medical Center Department of Laboratory Medicine
이남용 ( Lee Nam-Yong )
Samsung Medical Center Department of Laboratory Medicine
KMID : 1101220000320030096
Abstract
Early detection and treatment of human cytomegalovirus(CMV) infection is very important because CMV infection is major cause of morbidity and mortality after organ transplantation. CMV antigenemia assay has been reported to be very sensitive and specific for detection of CMV infection among many laboratory methods. We compared the results of CMV antigenemia(Clonab CMV kit; Biotest AG, Landsteinerstrasse，Dreiceich, Germany), CMV PCR, CMV culture and CMV IgM to evaluate their clinical usefulness. We compared 620 samples for CMV antigenemia tests, 2,272 samples for CMV culture, and 423 samples for CMV PCR tests between July 1997 and April 1998 in samsung medical center clinical microbiology For CMV test, the sensitivity of CMV culture, CMV antigenemia, and CMV PCR were 4.3%, 16.6% and 31.0%, respectively. Sixty seven patients were classified CMV antigenemia positive. The results of compared for CMV culture, CMV PCR, and CMV IgM antibody. For CMV antigenemia, the sensitivity of CMV PCR and CMV IgM antibody were 85.3%, 93.5% respectively. CMV antigenemia is thought to be useful for early diagnosis and follow- up of antiviral treatment as a quantitative and highly specific method. The sensitivity and specificity are very comparing to CMV antigenemia.
키워드
Human Cytomegalovirus; CMV antigenemia assay
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