fNIRS Assessment during an Emotional Stroop Task among Patients with Depression: Replication and Extension
Nishizawa Yoshitaka, Kanazawa Tetsufumi, Kawabata Yasuo, Matsubara Toshio, Maruyama Soichiro, Kawano Makoto, Kinoshita Shinya, Koh Jun, Matsuo Koji, Yoneda Hiroshi,
소속 상세정보
( Nishizawa Yoshitaka )
Osaka Medical College Department of Neropsychiatry
( Kanazawa Tetsufumi )
Osaka Medical College Department of Neropsychiatry
( Kawabata Yasuo )
Osaka Medical College Department of Neropsychiatry
( Matsubara Toshio )
Yamaguchi University Graduate School of Medicine Department of Neuroscience
( Maruyama Soichiro )
Osaka Medical College Department of Neropsychiatry
( Kawano Makoto )
Osaka Medical College Department of Neropsychiatry
( Kinoshita Shinya )
Osaka Medical College Department of Neropsychiatry
( Koh Jun )
Osaka Medical College Department of Neropsychiatry
( Matsuo Koji )
Yamaguchi University Graduate School of Medicine Department of Neuroscience
( Yoneda Hiroshi )
Osaka Medical College Department of Neropsychiatry
Abstract
Objective: Accumulated evidence collected via functional near-infrared spectroscopy (fNIRS) has been reported with regard to mental disorders. A previous finding revealed that emotional words evoke left frontal cortex activity in patients with depression. The primary aim of the current study was to replicate this finding using an independent dataset and evaluate the brain region associated with the severity of depression using an emotional Stroop task.
Methods: Oxygenized and deoxygenized hemoglobin recording in the brain by fNIRS on 14 MDD patients and 20 normal controls.
Results: Hyperactivated oxygenized hemoglobin was observed in the left frontal cortex on exposure to unfavorable stimuli, but no significant difference was found among patients with depression compared with healthy controls on exposure to favorable stimuli. This result is consistent with previous findings. Moreover, an evoked wave associated with the left upper frontal cortex on favorable stimuli was inversely correlated with the severity of depression.
Conclusion: Our current work using fNIRS provides a potential clue regarding the location of depression symptom severity in the left upper frontal cortex. Future studies should verify our findings and expand them into a precise etiology of depression.
키워드
Functional near-infrared spectroscopy (f-NIRS); Depression; Biomarker; Left frontal cortex
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