Current Clinical Applications of Diffusion-Tensor Imaging in Neurological Disorders
태우석, 함병주, 편성범, 강신혁, 김병조,
소속 상세정보
태우석 ( Tae Woo-Suk )
Korea University Brain Convergence Research Center
함병주 ( Ham Byung-Joo )
Korea University Brain Convergence Research Center
편성범 ( Pyun Sung-Bom )
Korea University Brain Convergence Research Center
강신혁 ( Kang Shin-Hyuk )
Korea University Brain Convergence Research Center
김병조 ( Kim Byung-Jo )
Korea University Brain Convergence Research Center
Abstract
Diffusion-tensor imaging (DTI) is a noninvasive medical imaging tool used to investigate the structure of white matter. The signal contrast in DTI is generated by differences in the Brownian motion of the water molecules in brain tissue. Postprocessed DTI scalars can be used to evaluate changes in the brain tissue caused by disease, disease progression, and treatment responses, which has led to an enormous amount of interest in DTI in clinical research. This review article provides insights into DTI scalars and the biological background of DTI as a relatively new neuroimaging modality. Further, it summarizes the clinical role of DTI in various disease processes such as amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Alzheimer's dementia, epilepsy, ischemic stroke, stroke with motor or language impairment, traumatic brain injury, spinal cord injury, and depression. Valuable DTI postprocessing tools for clinical research are also introduced.
키워드
diffusion-tensor imaging; diffusion-tensor imaging scalar; postprocessing; neurological disorders
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