Roles of Oncogenic Long Non-coding RNAs in Cancer Development
도현희, 김완연,
소속 상세정보
도현희 ( Do Hyun-Hee )
Korea National University of Education Department of Biology Education
김완연 ( Kim Wan-Yeon )
Korea National University of Education Department of Biology Education
Abstract
Long non-coding RNAs (lncRNAs) are classified as RNAs that are longer than 200 nucleotides and cannot be translated into protein. Several studies have demonstrated that lncRNAs are directly or indirectly involved in a variety of biological processes and in the regulation of gene expression. In addition, lncRNAs have important roles in many diseases including cancer. It has been shown that abnormal expression of lncRNAs is observed in several human solid tumors. Several studies have shown that many lncRNAs can function as oncogenes in cancer development through the induction of cell cycle progression, cell proliferation and invasion, anti-apoptosis, and metastasis. Oncogenic lncRNAs have the potential to become promising biomarkers and might be potent prognostic targets in cancer therapy. However, the biological and molecular mechanisms of lncRNA involvement in tumorigenesis have not yet been fully elucidated. This review summarizes studies on the regulatory and functional roles of oncogenic lncRNAs in the development and progression of various types of cancer.
키워드
breast cancer; colorectal cancer; glioblastoma; long non-coding RNA; non-small cell lung cancer; oncogenes
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