The Effects of Myrtle (Myrtus communis) and Clindamycin Topical Solution in the Treatment of Mild to Moderate Acne Vulgaris: A Comparative Split-Face Study
Salmanian Mahboobeh, Shirbeigi Laila, Hashem-Dabaghian Fataneh, Mansouri Parvin, Azizkhani Mohammad, Alavi Shiva, Ghobadi Ali,
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( Salmanian Mahboobeh )
Iran University of Medical Sciences Research Institute for Islamic and Complementary Medicine
( Shirbeigi Laila )
Tehran University of Medical Sciences School of Persian Medicine Department of Persian Medicine
( Hashem-Dabaghian Fataneh )
Iran University of Medical Sciences Research Institute for Islamic and Complementary Medicine
( Mansouri Parvin )
Tehran University of Medical Sciences Skin and Stem Cell Research Center
( Azizkhani Mohammad )
Traditional Medicine Specialist
( Alavi Shiva )
Tehran University of Medical Sciences Skin and Stem Cell Research Center
( Ghobadi Ali )
Iran University of Medical Sciences Research Institute for Islamic and Complementary Medicine
Abstract
Objectives: Although Acne vulgaris is a chronic skin disease, which its standard treatment causes therapeutic limitations and some common adverse effects, medicinal plants can be effective in treatment with low adverse effects as combination therapy. Myrtle (Myrtus Communis) has some beneficial properties, which has been administered topically and orally for some skin diseases in Persian medicine. This study aimed to compare the efficacy and safety of Myrtle formula and 1% clindamycin topical solution.
Methods: This was a split-face clinical trial that was done on 55 patients with mild to moderate acne vulgaris for 16 weeks. The patients received topical Myrtle solution to the right side of the face (group 1) and clindamycin solution to the left side (group 2) twice daily for 12 weeks. All participants were examined for the acne severity index (ASI) and total acne lesions counting (TLC) at certain times during the study. Then, they stopped using them for four weeks. They also did not take the drug in the final four weeks of the study.
Results: Forty-eight patients completed the study for 16 weeks; 40 (83.2%) patients were female and the rest of them were male. The mean age and standard deviation were 25.62 ± 7.62 years. After 12 weeks, the percentage changes of comedones, inflammatory lesions, ASI and TLC were significantly reduced in both groups (p < 0.001). The percentage change of inflammatory lesions and ASI decrease was significantly higher in the group 1 (p = 0.03). There was no significant difference in the incidence of side effects between the two groups. There was a more significant decrease in sebum percentage change in the group 1 (p = 0.003).
Conclusion: Myrtle lotion was effective and safe for the treatment of mild to moderate acne vulgaris.
키워드
acne vulgaris; myrtus communis; persian medicine; split-face
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