Gastric type mucinous endocervical adenocarcinoma of the uterine cervix: very rare and interesting case
박철민, 고현민, 박소연, 강혜심, 심순섭, 김성엽,
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박철민 ( Park Chul-Min )
Jeju National University Hospital Department of Obstetrics and Gynecology
고현민 ( Koh Hyun-Min )
Jeju National University Hospital Department of Pathology
박소연 ( Park So-Yun )
Jeju National University Hospital Department of Obstetrics and Gynecology
강혜심 ( Kang Hye-Sim )
Jeju National University Hospital Department of Obstetrics and Gynecology
심순섭 ( Shim Soon-Sup )
Jeju National University Hospital Department of Obstetrics and Gynecology
김성엽 ( Kim Sung-Yob )
Jeju National University Hospital Department of Obstetrics and Gynecology
Abstract
Gastric type mucinous endocervical adenocarcinomas of the uterine cervix (GAC) are a newly classified mucinous subtype with morphologically in 2014, WHO. They have a much more aggressiveness and show unusual metastatic patterns compared to usual type endocervical adenocarcinoma. They tend to present at higher stage and even in stage I, they have worse survival. Therefore, differential diagnosis of GAC from the usual type of endocervical adenocarcinoma is very important because they are related to a significant risk of recurrence and decreased 5-year disease-specific survival. Besides, GACs are mostly not associated with human papillomavirus (HPV) infection and p16 immunohistochemistry is also typically negative in GAC that is HPV-unassociated tumor. We report a very rare and interesting case of stage IB1 GAC with negative HPV DNA and p16.
키워드
Adenocarcinoma; Mucinous; Gastric type; Human papillomavirus
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