Impact of presence of antiphospholipid antibodies on in vitro fertilization outcome
홍연희, 김세정, 문경용, 김슬기, 지병철, 이원돈, 김석현,
소속 상세정보
홍연희 ( Hong Yeon-Hee )
Seoul National University Hospital Department of Obstetrics and Gynecology
김세정 ( Kim Se-Jeong )
Seoul National University Hospital Department of Obstetrics and Gynecology
문경용 ( Moon Kyoung-Yong )
Seoul National University College of Medicine Department of Obstetrics and Gynecology
김슬기 ( Kim Seul-Ki )
Seoul National University College of Medicine Department of Obstetrics and Gynecology
지병철 ( Jee Byung-Chul )
Seoul National University College of Medicine Department of Obstetrics and Gynecology
이원돈 ( Lee Won-Don )
Seoul Maria Fertility Hospital
김석현 ( Kim Seok-Hyun )
Seoul National University College of Medicine Department of Obstetrics and Gynecology
Abstract
Objective: To investigate prevalence of antiphospholipid antibody (APA) in Korean infertile women undergoing the first in vitro fertilization (IVF) treatment and to evaluate the influence of APA on the subsequent IVF outcomes.
Method: Two hundred nineteen infertile women who destined the first IVF were prospectively enrolled in 2 infertility centers. Male factor or uterine factor infertility and women with past or current endocrine or immunologic disorders were completely excluded. Plasma concentration of lupus anticoagulant was measured by clot-based method, and anticardiolipin antibody (IgG/IgM), and anti-β2-glycoprotein 1 antibody (IgG/IgM) was measured by enzyme-linked immunosorbent assay method before starting ovarian stimulation for IVF.
Results: APA was positive in 13 women (5.9%). Lupus anticoagulant was positive in 2 women (0.9%), anticardiolipin antibody was positive in 7 women (3.2%), and anti-β2-glycoprotein 1 antibody was positive in 4 women (1.8%). In 193 women entering embryo transfer, clinical characteristics and stimulation outcomes were comparable between APA-positive (n=12) and APA-negative group (n=181). The clinical pregnancy rate (66.7% vs. 45.9%), ongoing pregnancy rate (58.3% vs. 37.0%), and miscarriage rate (12.5% vs. 19.3%) were all similar between APA-positive and APA-negative group.
Conclusion: The prevalence of APA is low in Korean infertile women undergoing the first IVF cycle, and the presence of APA appears to neither decrease their first IVF success nor increase abortion rate.
키워드
Antiphospholipid antibody; In vitro fertilization; Infertility
원문 및 링크아웃 정보
등재저널 정보