Omega 3 Fatty Acids and COVID-19: A Comprehensive Review
Hathaway Donald, Pandav Krunal, Patel Madhusudan, Riva-Moscoso Adrian, Singh Bishnu Mohan, Patel Aayushi, Min Zar Chi, Singh-Makkar Sarabjot, Sana Muhammad Khawar, Sanchez-Dopazo Rafael, Desir Rockeven, Fahem Michael Maher Mourad, Manella Susan, Rodriguez Ivan, Alvarez Alina, Abreu Rafael,
소속 상세정보
( Hathaway Donald )
Larkin Health System Division of Research and Academic Affairs
( Pandav Krunal )
Larkin Health System Division of Research and Academic Affairs
( Patel Madhusudan )
Larkin Health System Division of Research and Academic Affairs
( Riva-Moscoso Adrian )
Larkin Health System Division of Research and Academic Affairs
( Singh Bishnu Mohan )
Larkin Health System Division of Research and Academic Affairs
( Patel Aayushi )
Larkin Health System Division of Research and Academic Affairs
( Min Zar Chi )
Larkin Health System Division of Research and Academic Affairs
( Singh-Makkar Sarabjot )
Larkin Health System Division of Research and Academic Affairs
( Sana Muhammad Khawar )
Larkin Health System Division of Research and Academic Affairs
( Sanchez-Dopazo Rafael )
Larkin Health System Division of Research and Academic Affairs
( Desir Rockeven )
Larkin Health System Division of Research and Academic Affairs
( Fahem Michael Maher Mourad )
Larkin Health System Division of Research and Academic Affairs
( Manella Susan )
Larkin Health System Division of Research and Academic Affairs
( Rodriguez Ivan )
Larkin Health System Division of Research and Academic Affairs
( Alvarez Alina )
Larkin Health System Division of Research and Academic Affairs
( Abreu Rafael )
Larkin Health System Division of Research and Academic Affairs
Abstract
The rapid international spread of severe acute respiratory syndrome coronavirus 2 responsible for coronavirus disease 2019 (COVID-19) has posed a global health emergency in 2020. It has affected over 52 million people and led to over 1.29 million deaths worldwide, as of November 13th, 2020. Patients diagnosed with COVID-19 present with symptoms ranging from none to severe and include fever, shortness of breath, dry cough, anosmia, and gastrointestinal abnormalities. Severe complications are largely due to overdrive of the host immune system leading to “cytokine storm”. This results in disseminated intravascular coagulation, acute respiratory distress syndrome, multiple organ dysfunction syndrome, and death. Due to its highly infectious nature and concerning mortality rate, every effort has been focused on prevention and creating new medications or repurposing old treatment options to ameliorate the suffering of COVID-19 patients including the immune dysregulation. Omega-3 fatty acids are known to be incorporated throughout the body into the bi-phospholipid layer of the cell membrane leading to the production of less pro-inflammatory mediators compared to other fatty acids that are more prevalent in the Western diet. In this article, the benefits of omega-3 fatty acids, especially eicosapentaenoic acid and docosahexaenoic acid, including their anti-inflammatory, immunomodulating, and possible antiviral effects have been discussed.
키워드
SARS-CoV-2; Omega-3 fatty acids; Eicosapentaenoic acid; Docosahexaenoic acid; COVID-19
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