The Effect of Grape Seed Extracts on Serum Paraoxonase Activities in Streptozotocin-Induced Diabetic Rats
Kiyici Aysel, Okudan Nilsel, Gokbel Hakki, Belviranli Muaz,
소속 상세정보
( Kiyici Aysel )
Selcuk University Department of Biochemistry
( Okudan Nilsel )
Selcuk University Meram Faculty of Medicine Department of Physiology
( Gokbel Hakki )
Selcuk University Meram Faculty of Medicine Department of Physiology
( Belviranli Muaz )
Selcuk University Meram Faculty of Medicine Department of Physiology
Abstract
Procyanidins, a group of flavonoids, are oligomeric forms of catechins that are abundant in red wine, grapes, cocoa, and apples. Paraoxonase acts as an antioxidant enzyme and protects low-density lipoprotein-cholesterol against oxidation. In our study we aimed to evaluate the effects of grape seed extract (GSE) on paraoxonase activities in streptozotocin-induced diabetic rats. Our study included four groups of rats: Group I (n?=?8), control; Group II (n?=?10), GSE-supplemented; Group III (n?=?6), streptozotocin-induced diabetic; and Group IV (n?=?7), GSE-supplemented diabetic rats. Serum paraoxonase activities were determined with a spectrophotometric method. Paraoxonase activities in Group III were significantly lower than in the other three groups (P?
키워드
diabetes; grape seed extract; paraoxonase
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