Antidepressant-Like Behavioral, Anatomical, and Biochemical Effects of Petroleum Ether Extract from Maca (Lepidium meyenii) in Mice Exposed to Chronic Unpredictable Mild Stress
Ai Zhong, Cheng Ai-Fang, Yu Yuan-Tao, Yu Long-Jiang, Jin Wenwen,
소속 상세정보
( Ai Zhong )
Huazhong University of Science and Technology College of Life Science and Technology Department of Biotechnology
( Cheng Ai-Fang )
Huazhong University of Science and Technology College of Life Science and Technology Department of Biotechnology
( Yu Yuan-Tao )
Huazhong University of Science and Technology College of Life Science and Technology Department of Biotechnology
( Yu Long-Jiang )
Huazhong University of Science and Technology College of Life Science and Technology Department of Biotechnology
( Jin Wenwen )
Huazhong University of Science and Technology College of Life Science and Technology Department of Biotechnology
Abstract
Maca has been consumed as a medical food in Peru for thousands of years, and exerts anxiolytic and antidepressant effects. Our present study aimed to evaluate the behavior and anatomical and biochemical effects of petroleum ether extract from maca (ME) in the chronic unpredictable mild stress (CUMS) model of depression in mice. Three different doses of maca extract (125, 250, and 500?mg/kg) were orally administrated in the six-week CUMS procedure. Fluoxetine (10?mg/kg) was used as a positive control drug. Maca extract (250 and 500?mg/kg) significantly decreased the duration of immobility time in the tail suspension test. After treatment with maca extract (250 and 500?mg/kg), the granule cell layer in the dentate gyrus appeared thicker. Maca extract (250 and 500?mg/kg) also induced a significant reduction in corticosterone levels in mouse serum. In mouse brain tissue, after six weeks of treatment, noradrenaline and dopamine levels were increased by maca extract, and the activity of reactive oxygen species was significantly inhibited. Serotonin levels were not significantly altered. These results demonstrated that maca extract (250 and 500?mg/kg) showed antidepressant-like effects and was related to the activation of both noradrenergic and dopaminergic systems, as well as attenuation of oxidative stress in mouse brain.
키워드
antidepressant; corticosterone; maca (Lepidium meyenii); monoamine neurotransmitters; reactive oxygen species; tail suspension test
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