The Relationship of Adiponectin/Leptin Ratio with Homeostasis Model Assessment Insulin Resistance Index and Metabolic Syndrome in Apparently Healthy Korean Male Adults
정찬희, 이은정, 최지훈, 배지철, 유승현, 김원준, 박철영, 목지오, 김철희, 이원영, 오기원, 박성우, 김선우,
소속 상세정보
정찬희 ( Jung Chan-Hee )
순천향대학교 의과대학 내분비내과
이은정 ( Rhee Eun-Jung )
성균관대학교 의과대학 강북삼성병원 내분비내과
최지훈 ( Choi Ji-Hun )
성균관대학교 의과대학 강북삼성병원 내과학교실
배지철 ( Bae Ji-Cheol )
성균관대학교 의과대학 강북삼성병원 내분비대사내과
유승현 ( Yoo Seung-Hyun )
성균관대학교 의과대학 강북삼성병원 내분비대사내과
김원준 ( Kim Won-Jun )
성균관대학교 의과대학 강북삼성병원 내분비내과
박철영 ( Park Cheol-Young )
성균관대학교 의과대학 강북삼성병원 내분비내과
목지오 ( Mok Ji-Oh )
순천향대학교 의과대학 내분비내과
김철희 ( Kim Chul-Hee )
순천향대학교 의과대학 내분비내과
이원영 ( Lee Won-Young )
성균관대학교 의과대학 강북삼성병원 내분비대사내과
오기원 ( Oh Ki-Won )
성균관대학교 의과대학 강북삼성병원 내분비대사내과
박성우 ( Park Sung-Woo )
성균관대학교 의과대학 강북삼성병원 내분비대사내과
김선우 ( Kim Sun-Woo )
성균관대학교 의과대학 강북삼성병원 내분비대사내과
KMID : 1199120100340040237
Abstract
Background: We investigated the relationships of adiponectin/leptin (A/L) ratio with cardiovascular risk factors, insulin resistance index, and metabolic syndrome (MS) in apparently healthy Korean male adults.
Methods: Sixty-eight male subjects were enrolled among the participants of an annual health check-up program (mean age, 55.1 years). Percent body fat (%) was measured using a bioelectric impedance analyzer. Serum leptin level was measured via radioimmunoassay, and adiponectin level was measured using an enzyme-linked immunosorbent assay. Homeostasis model assessment (HOMA)-insulin resistance (IR) index was calculated, and the presence of metabolic syndrome was assessed.
Results: Adiponectin, leptin, and A/L ratio showed significant correlations with percent body fat, lipid profile, and HOMA-IR. Mean leptin and HOMA-IR levels were significantly higher, while A/L ratio was significantly lower in subjects with MS. With increasing number of MS components, the mean values of leptin and HOMA-IR increased and the A/L ratio decreased. In multiple regression analysis, HOMA-IR was significantly correlated with triglyceride, fasting glucose, and A/L ratio, while A/L ratio was significantly correlated with body mass index and HOMA-IR. HOMA-IR and A/L ratio were significant predictors for each other after adjustment for other factors.
Conclusion: A/L ratio correlated well with lipid profile, HOMA-IR, and the presence and number of MS components in Korean male subjects.
키워드
Adiponectin/leptin ratio; Insulin resistance; Metabolic syndrome
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