Chrysanthemum morifolium inhibits inflammatory responses in and LPS-induced mouse peritoneal macrophages
나호정, 차동석, 전소라, 부영민, Jeong Won-Hwan, 전훈,
소속 상세정보
나호정 ( Na Ho-jeong )
우석대학교 약학대학
차동석 ( Cha Dong-Seok )
우석대학교 약학대학
전소라 ( Jeon So-ra )
우석대학교 약학대학 한약학과
부영민 ( Bu Young-Min )
우석대학교 약학대학
( Jeong Won-Hwan )
Gochang GukHwa festival Committee
전훈 ( Jeon Hoon )
우석대학교 약학대학
KMID : 1200820060060030161
Abstract
Chrysanthemum morifolium (CM) is a herb widely used in medicine for the treatment of a variety of diseases. In this study, using mouse peritoneal macrophages, we have examined whether CM affects nitric oxide (NO), tumor necrosis factor and interleukin (IL)-6 induced interferon and lipopolysaccharide (LPS). CM inhibits and LPS-induced NO in dose dependent manner. We also found that CM inhibits pro-inflammatory cytokine, and IL-6. The expression of cyclooxygenase-2 was reduced by CM. These finding means that CM can be used in controlling macrophages-mediated inflammatory disease.
키워드
Chrysanthemum morifolium;Nitric oxide;IL-6;COX-2
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