Transgenic fluorescent zebrafish lines that have revolutionized biomedical research
채종표, 최석용, 기윤, 김민중, 김석형, 이윤성, 박해철, 노현주,
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채종표 ( Choe Chong-Pyo )
Gyeongsang National University Division of Applied Life Sciences
최석용 ( Choi Seok-Yong )
Chonnam National University Medical School Department of Biomedical Sciences
기윤 ( Kee Yun )
Kangwon National University College of Biomedical Sciences Division of Biomedical Convergence
김민중 ( Kim Min-Jung )
Sookmyung Women’s University Department of Biological Science
김석형 ( Kim Seok-Hyung )
Jeju National University Department of Marine Life Sciences
이윤성 ( Lee Yoon-Sung )
Institute for Basic Science Center for Genomic Integrity
박해철 ( Park Hae-Chul )
Korea University College of Medicine Department of Biomedical Sciences
노현주 ( Ro Hyun-Ju )
Chungnam National University College of Bioscience and Biotechnology Department of Biological Sciences
Abstract
Since its debut in the biomedical research fields in 1981, zebrafish have been used as a vertebrate model organism in more than 40,000 biomedical research studies. Especially useful are zebrafish lines expressing fluorescent proteins in a molecule, intracellular organelle, cell or tissue specific manner because they allow the visualization and tracking of molecules, intracellular organelles, cells or tissues of interest in real time and in vivo. In this review, we summarize representative transgenic fluorescent zebrafish lines that have revolutionized biomedical research on signal transduction, the craniofacial skeletal system, the hematopoietic system, the nervous system, the urogenital system, the digestive system and intracellular organelles.
키워드
Zebrafish; Transgenic; Fluorescent; Signal; Skeletal; Hematopoietic; Nervous; Urogenital; Digestive; Organelle
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