Amiodarone-induced Hepatitis and Polyneuropathy
강현모, 강윤세, 김석현, 성재규, 강대영, 이현영, 이병석,
소속 상세정보
강현모 ( Kang Hyun-Mo )
충남대학교 의과대학 내과학교실
강윤세 ( Kang Yoon-Sae )
충남대학교 의과대학 내과학교실
김석현 ( Kim Seok-Hyun )
충남대학교 의과대학 내과학교실
성재규 ( Sung Jae-Kyu )
충남대학교 의과대학 내과학교실
강대영 ( Kang Dae-Young )
충남대학교 의과대학 병리학교실
이현영 ( Lee Heon-Young )
충남대학교병원 내과학교실
이병석 ( Lee Byung-Seok )
충남대학교 의과대학 내과학교실
KMID : 0338420070220030225
Abstract
Amiodarone chlorhydrate is a diiodated benzofuran derivative, and it is used to treat cardiac rhythm abnormalities. Hepatotoxicity is a relatively uncommon side effect of amiodarone, and symptomatic hepatic dysfunction occurs in fewer than 1% of the patients taking amiodarone. Cirrhosis is a rare complication that’s been confirmed in 12 cases. Peripheral neuropathy occurs in 10% of patients taking aminodarone. We report here on an unusual case of amiodarone-induced hepatotoxicity and peripheral neurotoxicity. A 75 year old man with normal liver function was given amiodarone for treating his atrial fibrillation and heart failure. He developed nausea, vomiting, muscle weakness and wasting after 17.8 months therapy with amiodarone (400 mg orally once per day). Liver biopsy showed the presence of foam cells in the hepatic sinusoids and Mallory bodies in the periportal hepatocytes on light microscopy.
Sural nerve biopsy showed demyelination, and nerve conduction studies showed mixed sensorimotor polyneuropathy. These observations show the necessity of monitoring the hepatic function and conducting neurologic examination of the patients treated with amiodarone.
키워드
Amiodarone;Hepatitis;Polyneuropathy
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