Tumor Necrosis Factor-¥á as a Predictor for the Development of Nonalcoholic Fatty Liver Disease: A 4-Year Follow-Up Study
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¼À±¿ë ( Seo Yun-Yong )
Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Gastroenterology
Á¶¿ë±Õ ( Cho Yong-Kyun )
Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Gastroenterology
¹èÁöö ( Bae Ji-Cheol )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Internal Medicine
¼¹ÌÇý ( Seo Mi-Hae )
Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Endocrinology and Metabolism
¹Ú¼¼Àº ( Park Se-Eun )
Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Endocrinology and Metabolism
ÀÌÀºÁ¤ ( Rhee Eun-Jung )
Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Endocrinology and Metabolism
¹Úö¿µ ( Park Cheol-Young )
Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Endocrinology and Metabolism
¿À±â¿ø ( Oh Ki-Won )
Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Endocrinology and Metabolism
ÀÌ¿ø¿µ ( Lee Won-Young )
Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Endocrinology and Metabolism
¹Ú¼º¿ì ( Park Sung-Woo )
Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Endocrinology and Metabolism
KMID : 0356620130280010041
Abstract
Background: Tumor necrosis factor (TNF)-¥á is associated with insulin resistance and systemic inflammatory responses. The aim of this study was to investigate the relationship between TNF-¥á and the development of nonalcoholic fatty liver disease (NAFLD) in a longitudinal study.
Methods: Three hundred and sixty-three apparently healthy subjects (mean age, 40.5¡¾6.1 years; male, 57.6%) without NAFLD were enrolled in 2003. Anthropometric and laboratory measurements were performed. The participants were grouped into tertiles according to their serum TNF-¥á levels from samples taken in 2003. At a 4-year follow-up, we compared the odds ratios (ORs) of the development of NAFLD according to the tertiles of TNF-¥á levels measured in 2003.
Results: At the 4-year follow-up, the cumulative incidence of NAFLD was 29.2% (106/363). The group that developed NAFLD had higher levels of TNF-¥á than those in the group without NAFLD (3.65¡¾1.79 pg/mL vs. 3.15¡¾1.78 pg/mL; P=0.016). When the 2003 serum TNF-¥á levels were categorized into tertiles: incidence of NAFLD observed in 2007 was significantly higher with increasing tertiles (22.6%, 35.8%, and 41.5%, respectively; P<0.05). The risk of developing NAFLD was significantly greater in the highest tertile of TNF-¥á than in the lowest tertile after adjusting for age, smoking, and BMI (OR, 2.20; 95% confidence interval, 1.12 to 4.01; P<0.05).
Conclusion: Higher serum TNF-¥á levels in subjects without NAFLD were associated with the development of NAFLD. The results of study might suggest a pathologic role of inflammation in NAFLD.
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Inflammation;Non-alcoholic fatty liver disease;Tumor necrosis factor-alpha
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