Anaplastic Thyroid Carcinoma Following Radioactive Iodine Therapy for Graves’ Disease
김순화, 김희영, 최동섭, 김신곤, 정광윤,
소속 상세정보
김순화 ( Kim Sun-Hwa )
Korea University College of Medicine Department of Internal Medicine
김희영 ( Kim Hee-Young )
Korea University College of Medicine Department of Internal Medicine
최동섭 ( Choi Dong-Seop )
Korea University College of Medicine Department of Internal Medicine
김신곤 ( Kim Sin-Gon )
Korea University College of Medicine Department of Internal Medicine
정광윤 ( Jung Kwang-Yoon )
Korea University College of Medicine Department of Otolaryngology-Head and Neck Surgery
KMID : 0356620130280010061
Abstract
Radioactive iodine (RAI) therapy has been used as a treatment option for Graves’ disease, and it has been widely accepted to be safe. On the other hand, some evidence suggests that RAI therapy is possibly associated with a small increased risk of thyroid cancer. Herein, we report a rare case of anaplastic thyroid carcinoma (ATC) associated with Graves’ disease, following RAI treatment. A 42-year-old woman had been diagnosed with Graves’ disease and although she was treated with an antithyroid drug, she remained in a hyperthyroid state, which led to two RAI treatments. More than 10 years later, the patient revisited our clinic due to hoarseness, dysphagia, and dyspnea, which had lasted for 2 months. Neck computed tomography suggested thyroid carcinoma and a lymph node biopsy showed metastatic papillary carcinoma. The patient underwent total thyroidectomy and was finally diagnosed as having an ATC. It is not clear if the occurrence of ATC reported here was influenced by the RAI therapy or alternatively, it may only represent the delayed recognition of a rare change in the natural history of Graves’ disease. Nevertheless, this report is worthwhile since it presents a very rare case of ATC that occurred eleven years after the RAI therapy for Graves’ disease.
키워드
Thyroid cancer;anaplastic;Graves disease;Radioactive iodine therapy
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