Association of Serum Adipocyte-Specific Fatty Acid Binding Protein with Fatty Liver Index as a Predictive Indicator of Nonalcoholic Fatty Liver Disease
전원선, 박세은, 이은정, 박철영, 오기원, 박성원,
소속 상세정보
전원선 ( Jeon Won-Seon )
Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Internal Medicine
박세은 ( Park Se-Eun )
Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Internal Medicine
이은정 ( Rhee Eun-Jung )
Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Internal Medicine
박철영 ( Park Cheol-Young )
Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Internal Medicine
오기원 ( Oh Ki-Won )
Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Internal Medicine
박성원 ( Park Sung-Won )
Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Internal Medicine
KMID : 0356620130280040283
Abstract
Background: Adipocyte-specific fatty acid-binding protein (A-FABP) is a cytoplasmic protein expressed in macrophages and adipocytes and it plays a role in insulin resistance and metabolic syndrome. Recently, the fatty liver index (FLI) was introduced as an indicator of nonalcoholic fatty liver disease (NAFLD). In this study, we aimed to investigate the relationship between baseline serum A-FABP levels and FLI after 4 years in apparently healthy subjects.
Methods: A total of 238 subjects without a past history of alcoholism or hepatitis were recruited from a medical check-up program. The NAFLD state was evaluated 4 years later in the same subjects using FLI. Fatty liver disease was diagnosed as diffusely increased echogenicity of the hepatic parenchyma compared to the kidneys, vascular blurring, and deep-echo attenuation. NAFLD was defined as subjects with fatty liver and no history of alcohol consumption (>20 g/day).
Results: Baseline serum A-FABP levels were significantly associated with FLI after adjustment for age and sex (P<0.001). The subjects with higher A-FABP levels had a higher mean FLI (P for trend=0.006). After adjusting for age and sex, serum A-FABP levels at baseline were shown to be significantly associated with FLI as a marker of development of NAFLD after 4 years (odds ratio, 2.68; 95% confidence interval, 1.24 to 5.80 for highest tertile vs. lowest tertile; P=0.012).
Conclusion: This study demonstrated that higher baseline serum A-FABP levels were associated with FLI as a predictive indicator of NAFLD after 4 years of follow-up in healthy Korean adults.
키워드
Fatty acid-binding proteins; Adipocytes; Non-alcoholic fatty liver disease; Ultrasonography
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