Rhabdomyolysis and Acute Kidney Injury Associated with Hypothyroidism and Statin Therapy
Ahn Pyoung, 민현준, 박상현, Lee Byoung-Mu, 최명진, 윤정우, 구자룡,
소속 상세정보
( Ahn Pyoung )
Hallym University Chuncheon Sacred Heart Hospital Department of Internal Medicine
민현준 ( Min Hyun-Jun )
Hallym University Chuncheon Sacred Heart Hospital Department of Internal Medicine
박상현 ( Park Sang-Hyun )
Hallym University Chuncheon Sacred Heart Hospital Department of Internal Medicine
( Lee Byoung-Mu )
Hallym University Chuncheon Sacred Heart Hospital Department of Internal Medicine
최명진 ( Choi Myung-Jin )
Hallym University Chuncheon Sacred Heart Hospital Department of Internal Medicine
윤정우 ( Yoon Jong-Woo )
Hallym University Chuncheon Sacred Heart Hospital Department of Internal Medicine
구자룡 ( Koo Ja-Ryong )
Hallym University Dongtan Sacred Heart Hospital Department of Internal Medicine
KMID : 0356620130280040331
Abstract
Rhabdomyolysis is a syndrome involving the breakdown of skeletal muscle that causes myoglobin and other intracellular proteins to leak into the circulatory system, resulting in organ injury including acute kidney injury. We report a case of statin-induced rhabdomyolysis and acute kidney injury that developed in a 63-year-old woman with previously undiagnosed hypothyroidism. Untreated hypothyroidism may have caused her hypercholesterolemia requiring statin treatment, and it is postulated that statin-induced muscle injury was aggravated by hypothyroidism resulting in her full-blown rhabdomyolysis. Although this patient was successfully treated with continuous venovenous hemofiltration and L-thyroxin replacement, rhabdomyolysis with acute kidney injury is a potentially life-threatening disorder. Physicians must pay special attention to the possible presence of subclinical hypothyroidism when administering statins in patients with hypercholesterolemia.
키워드
Hypothyroidism; Rhabdomyolysis; Statins
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