대장 및 직장암 환자에서 말초혈, 하장간막정맥혈, 담즙 및 직장 분비물 간의 CEA치의 의의와 상관관계
Comparision and Correlation of Carcinoembryonic Antigen Levels between Peripheral Blood and Inferior Mesenteric Vein Blood, and Gallbladder Bile, and Rectal Secretion
소속 상세정보
도병수/Byung Soo Do
정연웅/김상운/김재황/심민철/권굉보/Yon Woong Chung/Sang Woon Kim/Jae Hwang Kim/Min Chul Shim/Koing Bo Kwun
KMID : 0356719910070020105
Abstract
The usefulness of serical CEA(carcinoembryonic antigen) determinations in s1aging,
detection, prognosis monitoring of therapy in patients with colorectal cancer has been
reported frequently during past the 20 years.
CEA in now the most widely used and to most useful marker for many cancers,
including those of the clown, lung, pancreas, and breast.
In this study, in order to clarify the mechanism by which CEA is released into
peripheral blood, bile through the liver and rectal secretion, 20 patients with cotorectal
cancer were examined for the correlation between CEA levels in peripheral and inferior
mesenteric vein(IMV) blood, and gallbladder bile, and rectal secretion. They were also
examined for the change of CEA levels in IMV blood during operation immediately after
laparotomy and after resection of the cancer lesions. 20 patients of benign anal disease
(hemorroid, anal fistula and fissure) were included in this study as control group.
The results were as follows:
1) The mean CEA level of peripheral blood in colorectal cancer patients
was
significantly higher than that of Peripheral blood in benign anal disease Patients. In
colorectal cancer group; 2.9 ± 1.52 ng/ml, In benign anal disease group: 0.9=0.51 ng/
ml(P≤ 0.0001).
2) The mean CEA level in IMV blood during operation was significantly higher than
that of peipheral blood in colorectal(cancer) patients. In IMV blood: 5.3 = 4.5 ng/ml, In
peripheral blood; 2.9± 1.92 ng/ml(p≤ 0.05).
3) The mean CEA level in IMV 1기cod immediately after laparotomy(5.3±4.54 ng/ml)
was not significantly different from that in IMV blood after the resection of cancer
lesions(5.6±5.18 ng/ml)
4) Gallbladder bile CEA levels were observed in 4 patients with hepatic metastasis
from the colorectal cancer. In 2 patients;>80ng/ml, In one patient; 12.0 ng/ml and the
other one patient; 5.6 ng/ml.
5) The CEA levels in rectal secretion of the Patients with benign and malignant
disease were high as > 80ng/ml.
키워드
Portal Vein; Carcinoembryonic Antigen(CEA);
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