인체대장암에서의 Cyclin 유전자의 발현
Expression of Cretin Genes in Colorectal Carcinomas
백원기, 문성희, 서성일, 박종욱, 배옥석, 최병길, 서민호,
소속 상세정보
백원기 ( Baek Won-Ki )
계명대학교 의과대학 미생물학교실
문성희 ( Moon Sung-Hee )
계명대학교 의과대학 가정의학교실
서성일 ( Suh Seong-Il )
계명대학교 의과대학 미생물학교실
박종욱 ( Park Jong-Wook )
계명대학교 의과대학 면역학교실
배옥석 ( Bae Ok-Suk )
계명대학교 의과대학 외과학교실
최병길 ( Choi Byung-Gil )
계명대학교 의과대학 면역학교실
서민호 ( Suh Min-Ho )
계명대학교 의과대학 미생물학교실
KMID : 0356719960120020239
Abstract
A fundamental cause of cancer is changed properties of genetic material, which may deregulate normal development of the tissue or Provide selective growth advantage to the tumor cell. This deregulation of cell proliferation results from altered production of a handful of proteins that play key roles in progression through the eucaryotic cell cycle. Cyclins are prime cell cycle regulators and are central to the control of major check points in eucaryotic cells. Cyclins were first identified in marine invertebrates on the basis of their dramatic cell cycle periodicity during meiotic and early mitotic divisions.
More than 30 cyclins sequences are now available for comparison. Cyclins function by forming a complex with and activating a family of cyclin-dependent protein kineses(COKs), at various stages in the cell cycle. They fall into three categories: A-type, B-type, and G1 cyclins(cycling C, Dl-D3, and E). In this study, the abundance of cyclins(A, B, C, Dl, E) mRNA expression in normalcolon(n=6), primary(n=6) and metastatic(n=1) colorectal carcinomas, and 3 colon cancer
cell lines were investigated by RT-PCR method. Expression of examined cyclin genes(A,B, C, Dl and E) were increased in all cancer tissues and cell lines. Gene expression of cyclic Dl in 1 cancer tissue and its metastatic cancer tissue, and cyclin I in cell lines(C2A, HT-29) were remarkably increased.
키워드
Colorectal Neoplasms;Cyclin
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