한국인 대장암에 있어서 전이관련 유전자의 발현
Expression of Tumor Metastasis Related Genes in Korean Colorectal Cancers and Cell lines
배옥석, 서성일, 전소영,
소속 상세정보
배옥석 ( Bae Ok-Suk )
계명대학교 의과대학 외과학교실
서성일 ( Suh Seong-Il )
계명대학교 의과대학 미생물학교실
전소영 ( Jun So-Young )
계명대학교 의과학연구소
KMID : 0356719980140010011
Abstract
We studied the expressions of E-cadherin, MMP-7 and CD44V in colorectal cancer and their corresponding normal mucosa using RT-PCR. From the 26 patients whom a com parative study of clinical and histopathological data is available, MMP-7 and CD44V were significantly enhanced in cancer and their metastatic tissues, compared with their normal mucosa. E-cadherin did not reveal any difference between cancer and normal mucosa. The relashionship between these genes and colorectal cancer development can not be confirmed by this study, however CD44v and MMP-7 may be associated with metastasis of colorectal cancer.
키워드
Colorectal cancer;CD44v;MMP 7;E cadherin
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