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Small Flat Adenocarcinoma of the Colon Arising from Familial Adenomatous Polyposis Patient: Suggesting de novo Origin
¹Úµ¿±¹, À̹Îö, ÀüÈ£Áø, ÀÌÂù¿µ, ±èÁ¤ÅÃ, Á¤¹Î, ¹ÚÁ¾±Ç, ·ùÁø¿ì,
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¹Úµ¿±¹ ( Park Dong-Kook )
´Ü±¹´ëÇб³ ÀÇ°ú´ëÇÐ ÀϹݿܰúÇб³½Ç
À̹Îö ( Lee Min-Chul )
´Ü±¹´ëÇб³ ÀÇ°ú´ëÇÐ ÇغÎÇб³½Ç
ÀüÈ£Áø ( Jun Ho-Jin )
´Ü±¹´ëÇб³ ÀÇ°ú´ëÇÐ ÀϹݿܰúÇб³½Ç
ÀÌÂù¿µ ( Lee Chan-Young )
´Ü±¹´ëÇб³ ÀÇ°ú´ëÇÐ ÀϹݿܰúÇб³½Ç
±èÁ¤Åà ( Kim Jung-Teak )
´Ü±¹´ëÇб³ ÀÇ°ú´ëÇÐ ÀϹݿܰúÇб³½Ç
Á¤¹Î ( Jung Min )
´Ü±¹´ëÇб³ ÀÇ°ú´ëÇÐ ÀϹݿܰúÇб³½Ç
¹ÚÁ¾±Ç ( Park Jong-Kweon )
´Ü±¹´ëÇб³ ÀÇ°ú´ëÇÐ ÀϹݿܰúÇб³½Ç
·ùÁø¿ì ( Ryu Jin-Woo )
´Ü±¹´ëÇб³ ÀÇ°ú´ëÇÐ ÀϹݿܰúÇб³½Ç
KMID : 0356719980140030655
Abstract
Most adenocarcinomas of the colorectum arise in a visible benign precursor lesion, the adenoma, which is a monoclonal proliferation of dysplastic nonmalignant epithelial cells. Adenoma-adenocarcinoma sequence has been represented as the predominat pathogenetic pathway. But a small flat depressed colon cancer is characterized by non-polypoid growth pattem with no association of adenomatous tissues, which has tendency to early submucosal invasion and lymph node metastasis even in very small lesion (<10 mm). It supports de novo carcinogenesis of colorectal cancer, although most colorectal cancerarise in pre-existing adenoma. We report a case of small float colon adenocarcinoma arising in normal colonic epithelium rather than adenomatous polyp in familial adenomatous polyposis syndrome.
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Small flat adenocarcinoma;Colon
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