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°¡Á·¼º ¿ëÁ¾Áõ ȯÀÚ¿¡¼­ ¹ß»ýÇÑ de novo±â¿øÀ» ½Ã»çÇÏ´Â ¼ÒÇü ÆíÆò ¼±¾Ï 1¿¹ º¸°í Small Flat Adenocarcinoma of the Colon Arising from Familial Adenomatous Polyposis Patient: Suggesting de novo Origin

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¹Úµ¿±¹, À̹Îö, ÀüÈ£Áø, ÀÌÂù¿µ, ±èÁ¤ÅÃ, Á¤¹Î, ¹ÚÁ¾±Ç, ·ùÁø¿ì,
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¹Úµ¿±¹ ( Park Dong-Kook ) 
´Ü±¹´ëÇб³ ÀÇ°ú´ëÇÐ ÀϹݿܰúÇб³½Ç

À̹Îö ( Lee Min-Chul ) 
´Ü±¹´ëÇб³ ÀÇ°ú´ëÇÐ ÇغÎÇб³½Ç
ÀüÈ£Áø ( Jun Ho-Jin ) 
´Ü±¹´ëÇб³ ÀÇ°ú´ëÇÐ ÀϹݿܰúÇб³½Ç
ÀÌÂù¿µ ( Lee Chan-Young ) 
´Ü±¹´ëÇб³ ÀÇ°ú´ëÇÐ ÀϹݿܰúÇб³½Ç
±èÁ¤Åà( Kim Jung-Teak ) 
´Ü±¹´ëÇб³ ÀÇ°ú´ëÇÐ ÀϹݿܰúÇб³½Ç
Á¤¹Î ( Jung Min ) 
´Ü±¹´ëÇб³ ÀÇ°ú´ëÇÐ ÀϹݿܰúÇб³½Ç
¹ÚÁ¾±Ç ( Park Jong-Kweon ) 
´Ü±¹´ëÇб³ ÀÇ°ú´ëÇÐ ÀϹݿܰúÇб³½Ç
·ùÁø¿ì ( Ryu Jin-Woo ) 
´Ü±¹´ëÇб³ ÀÇ°ú´ëÇÐ ÀϹݿܰúÇб³½Ç

Abstract


Most adenocarcinomas of the colorectum arise in a visible benign precursor lesion, the adenoma, which is a monoclonal proliferation of dysplastic nonmalignant epithelial cells. Adenoma-adenocarcinoma sequence has been represented as the predominat pathogenetic pathway. But a small flat depressed colon cancer is characterized by non-polypoid growth pattem with no association of adenomatous tissues, which has tendency to early submucosal invasion and lymph node metastasis even in very small lesion (<10 mm). It supports de novo carcinogenesis of colorectal cancer, although most colorectal cancerarise in pre-existing adenoma. We report a case of small float colon adenocarcinoma arising in normal colonic epithelium rather than adenomatous polyp in familial adenomatous polyposis syndrome.

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Small flat adenocarcinoma;Colon

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KCI
KoreaMed
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