°áÁ÷Àå¾ÏÁ¾¿¡¼ÀÇ ¸é¿ªÁ¶Á÷ÇÐÀû CEA ¿°»ö¾ç»ó ¹× PCNA¹ßÇöÀ²¿¡ ´ëÇÑ ¿¬±¸
A Study on the Relationship between CEA Immunohistochemical Findings and Expression Rate of PCNA and Clinicopathologic Factors of Colorectal Cancers
È«°üÈñ, Àüº´¹Î, ±èÁ¾ÀÍ,
¼Ò¼Ó »ó¼¼Á¤º¸
È«°üÈñ ( Hong Kwan-Hee )
ÀÎÁ¦´ëÇб³ ÀÇ°ú´ëÇÐ ºÎ»ê¹éº´¿ø ¿Ü°úÇб³½Ç
Àüº´¹Î ( Jun Byung-Min )
ÀÎÁ¦´ëÇб³ ºÎ»ê¹éº´¿ø ÀϹݿܰúÇб³½Ç
±èÁ¾ÀÍ ( Kim Jong-Ik )
ÀÎÁ¦´ëÇб³ ºÎ»ê¹éº´¿ø ÀϹݿܰúÇб³½Ç
KMID : 0356719980140040725
Abstract
Immunohistochemical study was performed for CEA staining patterns and PCNA indices. And the relationship between immunohistochemical findings and well-known clinical prognostic factors on the purpose of the clinical usefulness was evaluated. In forty seven cases of surgically removed colorectal carcinomas, the results were as follows; CEA staining patterns were apical (17 cases) and cytoplasmic (30 cases) type. Carcinomas with cyto plasmic pattern for CEA revealed more advanced Dukes¡¯ stage and more undifferentiated type and higher incidence of lymph node metastasis and were correlated with increased serum CEA levels. But PCNA indices showed no correlation with the Dukes¡¯ stage, histologic grade and CEA staining patterns. The cytoplasmic pattern of CEA immunohistochemistry may be a useful marker suggesting more aggressive biologic behavior of the colorectal carcinomas.
Å°¿öµå
CEA (Carcinoembryonic antigen);PCNA (Proliferating cell nuclear antigen);Colorectal carcinoma
¿ø¹® ¹× ¸µÅ©¾Æ¿ô Á¤º¸
µîÀçÀú³Î Á¤º¸