대장암환자에서 혈중 총 항산화능의 변화
Changes of Antioxidant Capacity in Colorectal Cancer Patients
권영득, 이한일, 박기혁, 주대현, 박성환, 유용운, 박기호, 전창호, 천종율, 김진천,
소속 상세정보
권영득 ( Kwon Young-Deuk )
대구효성가톨릭대학교 의과대학 외과학교실
이한일 ( Lee Han-Il )
대구효성가톨릭대학교 의과대학 외과학교실
박기혁 ( Park Ki-Hyuk )
대구효성가톨릭대학교 의과대학 외과학교실
주대현 ( Joo Dae-Hyun )
대구효성가톨릭대학교 의과대학 외과학교실
박성환 ( Park Sung-Hwan )
대구효성가톨릭대학교 의과대학 외과학교실
유용운 ( Yoo Young-Oon )
대구효성가톨릭대학교 의과대학 외과학교실
박기호 ( Park Ki-Ho )
대구효성가톨릭대학교 의과대학 외과학교실
전창호 ( Jeon Chang-Ho )
대구효성가톨릭대학교 의과대학 임상병리학교실
천종율 ( Chun Jong-Youl )
대구보훈병원 일반외과
김진천 ( Kim Jin-Cheon )
울산대학교 의과대학 외과학교실
KMID : 0356719990150030151
Abstract
Purpose: Free radicals are defined as any species capable of independent existence that contains one or more unpaired electrons and they have the effects on carcinogenesis and tumor progression by causing mutations on genetic structure or suppressing repair of mu tated DNA. This study was aimed to identify changes of antioxidant capacity in carcino genesis and tumor progression of colorectal cancer (CRC).
Methods: We studied the level of serum antioxidant capacity using ABTS technique for 34 CRC patients who were operated between July 1997 and January 1998 at department of surgery, Taegu Catholic Medical Center and compared with 38 persons who had normal value of liver function during the same period.
Results: CRC patients showed decreased serum antioxidant capacity level compared to that of control group (CRC male 1.23 0.15 mmol/L, CRC female 1.11 0.13 mmol/L, control male 1.40 0.15, control female 1.35 0.11 mmol/L). Changes of antioxidant capacity levels were not correlated with stages, even though the marginal difference between T-stages (T1/2 1.23 0.10 mmol/L, T3/4 1.16 0.15 mmol/L).
Conclusion: Free radicals may be the causative agent of colorectal carcinogenesis and can be associated with early phase of carcinogenesis rather than tumor progression.
키워드
Antioxidant capacity;Colorectal cancer
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