대장암의 간전이 절제 후 생존에 영향을 미치는 인자
Prognostic Factors after Hepatic Resection for Metastatic Colorectal Cancer
김희철, 김창남, 홍현기, 이동희, 유창식, 이제환, 김태원, 김진천,
소속 상세정보
김희철 ( Kim Hee-Cheol )
울산대학교 의과대학 외과학교실
김창남 ( Kim Chang-Nam )
을지대학교 의과대학 외과학교실
홍현기 ( Hong Hyun-Ki )
울산대학교 의과대학 외과학교실
이동희 ( Lee Dong-Hee )
울산대학교 의과대학 외과학교실
유창식 ( Yu Chang-Sik )
울산대학교 의과대학 외과학교실
이제환 ( Lee Je-Hwan )
울산대학교 의과대학 서울중앙병원 내과학교실
김태원 ( Kim Tae-Won )
울산대학교 의과대학 서울중앙병원 내과학교실
김진천 ( Kim Jin-Cheon )
울산대학교 의과대학 외과학교실
KMID : 0356720000160020087
Abstract
Metastases to the liver from carcinoma of the colon and rectum occur as many as 80% of cases. As resection of metastases is proven to enhance survival and to reduce hepatic recurrence, the criteria for selection of patients and surgery type appear to be indispensable.
Purpose: The aim of this study was to assess the prognostic factors after hepatic resection for metastatic colorectal cancer and propose the optimal surgical principles for resection of metastatic colorectal cancer.
Methods: Sixty-three patients who underwent initial hepatic resection for liver metastases from colorectal cancer between 1989 and 1998 were analyzed regarding clinical and pathologic parameters.
Results: Overall 5-year survival rate was 32%. Preoperative serum CEA level and resection margin of metastatic tumors were found to be significant predictors for poor long-term outcome. Resection margin of greater than 5 mm was closely associated with better survival. In multivariate analysis, resection margin alone was an independent prognostic factor.
Conclusion: Preoperative serum CEA level and surgical resection margin may affect the outcome for the patients who underwent hepatic resection for metastatic colorectal cancer. Surgical resection margin must be kept enough to avoid re-recurrence or metastasis during hepatic resection for metastatic colorectal cancer.
키워드
Colorectal cancer;Hepatic metastasis;Prognostic factors;Serum CEA;Resection margin
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