결장 및 직장암의 근치적 절제술 후 CEA치의 의의
The Significance of Serum Carcinoembryonic Antigen in Curative Surgery of Colorectal Cancer
이문섭, 정병욱, 정기훈, 서정욱, 안우섭, 배성한, 오민구, 이준희, 양창헌,
소속 상세정보
이문섭 ( Lee Mun-Sub )
동국대학교 의과대학 외과학교실
정병욱 ( Jung Byeong-Wuk )
동국대학교 의과대학 외과학교실
정기훈 ( Jung Ki-Hoon )
동국대학교 의과대학 외과학교실
서정욱 ( Seo Jung-Ook )
동국대학교 의과대학 외과학교실
안우섭 ( Ahn Woo-Sup )
동국대학교 의과대학 외과학교실
배성한 ( Bae Sung-Han )
동국대학교 의과대학 외과학교실
오민구 ( Oh Min-Gu )
동국대학교 의과대학 외과학교실
이준희 ( Lee Jun-Hee )
동국대학교 의과대학 외과학교실
양창헌 ( Yang Chang-Heon )
동국대학교 의과대학 내과학교실
KMID : 0356720000160040260
Abstract
Purpose: Carcinoembryonic antigen (CEA) in now the most widely used and the most useful marker for many cancers, including those of the colon, lung, pancreas, and breast. Also CEA is widely used for detection, staging, recurrence, and assessing the response to therapy in colorectal cancer.
Methods: From 1992 to 1998 the clinical value of the pre- and postoperative serum levels of CEA who underwent curative surgery at Department of General Surgery, College of Medicine, Dongguk University KyungJu Hospital, in 140 s patient with colorectal cancer with abnormal levels of CEA (＞or=5 ng/ml) was investigated.
Results: The results are as follows: 1) The positive rate of preoperative CEA level was 47%, so preoperative CEA level measurement was not useful as screening test for colorectal cancer. 2) There was no significant association between abnormal CEA level and the location of tumor. 3) There was significant association between increased levels of preoperative serum CEA and lymph node metastases. 4) The incidence of preoperatively elevated CEA levels in Dukes
stages A, B, C, and D was 0%, 27%, 63%, 71%, respectively. There was significant association between increased levels of the preoperative serum CEA and the progressive stages of colorectal cancers. 5) There was no significant association between abnormal CEA level and histologic differentiation of tumor. In addition, there was no significant association between abnormal CEA level and ploidy status of tumor. 6) The recurrence rate was 20% and 77% in patients with preoperative levels of CEA＜5 ng/ml and ＞5 ng/ml, respectively. 7) The recurrence rate was 11% and 64% in patients with postoperative levels of CEA ＜5 ng/ml and ＞5 ng/ml, respectively. 8) Considering as normal CEA levels up to 5.0 ng/ml, sensitivity was found to be 77%, specificity, 80%, and predictive value of an elevated CEA concentration, 77%.
Conclusion: In conclusion, it is suggested that measurement of preoperative and serial postoperative CEA is very useful in assessing the prognosis and in detecting recurrences in colorectal cancer.
키워드
Colorectal cancer;CEA
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